Blar i NIVA Open Access Archive på forfatter "Scholz, Stefan"

Viser treff 1-5 av 5

    • Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations 

      Bajard, Lola; Adamovsky, Ondrej; Audouze, Karine; Baken, Kirsten; Barouki, Robert; Beltman, Joost B.; Beronius, Anna; Bonefeld-Jørgensen, Eva Cecilie; Cano-Sancho, German; de Baat, Milo L.; Di Tillio, Filippo; Fernandez, Mariana F.; FitzGerald, Rex E.; Gundacker, Claudia; Hernández, Antonio F.; Hilscherova, Klara; Karakitsios, Spyros; Kuchovska, Eliska; Long, Manhai; Luijten, Mirjam; Majid, Sanah; Marx-Stoelting, Philip; Mustieles, Vicente; Negi, Chander K.; Sarigiannis, Dimosthenis; Scholz, Stefan; Sovadinova, Iva; Stierum, Rob; Tanabe, Shihori; Tollefsen, Knut-Erik; van den Brand, Annick D.; Vogs, Carolina; Wielsøe, Maria; Wittwehr, Clemens; Blaha, Ludek (Peer reviewed; Journal article, 2022)
      While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate ...

    • Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA) 

      Tollefsen, Knut Erik; Scholz, Stefan; Cronin, Mark T.; Edwards, Stephen W.; de Knecht, Joop; Crofton, Kevin; Garcia-Reyero, Natalia; Hartung, Thomas; Worth, Andrew; Patlewicz, Grace (Journal article; Peer reviewed, 2014)
      Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal ...

    • Limitations and Uncertainties of Acute Fish Toxicity Assessments Can Be Reduced Using Alternative Methods 

      Paparella, Martin; Scholz, Stefan; Belanger, Scott; Braunbeck, Thomas; Bicherel, Pascal; Connors, Kristin; Faßbender, Christopher; Halder, Marlies; Lillicrap, Adam David; Liska, Roman; Schirmer, Kristin; Stoddart, Gilly; Thomas, Paul; Walter-Rohde, Susanne (Peer reviewed; Journal article, 2021)
      Information about acute fish toxicity is routinely required in many jurisdictions for environmental risk assessment of chem­icals. This information is typically obtained using a 96-hour juvenile fish test for lethality ...

    • OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing 

      Busquet, François; Strecker, Ruben; Rawlings, Jane M.; Belanger, Scott E.; Braunbeck, Thomas; Carr, Gregory J.; Cenijn, Peter; Fochtman, Przemyslaw; Gourmelon, Anne; Hübler, Nicole; Kleensang, André; Knöbel, Melanie; Kussatz, Carola; Legler, Juliette; Lillicrap, Adam David; Martínez-Jerónimo, Fernando; Polleichtner, Christian; Rzodeczko, Helena; Salinas, Edward; Schneider, Katharina E.; Scholz, Stefan; van den Brandhof, Evert-Jan; van der Ven, Leo T.M.; Walter-Rohde, Susanne; Weigt, Stefan; Witters, Hilda; Halder, Marlies (Journal article; Peer reviewed, 2014)
      The OECD validation study of the zebrafish embryo acute toxicity test (ZFET) for acute aquatic toxicity testing evaluated the ZFET reproducibility by testing 20 chemicals at 5 different concentrations in 3 independent runs ...

    • Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals 

      Petersen, Karina; Fetter, Eva; Kah, Olivier; Brion, François; Scholz, Stefan; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2013)
      Endocrine disrupting chemicals and especially oestrogen receptor (ER) agonists have been extensively studied over the years due to their potential effects on sexual development and reproduction in vertebrates, notably fish. ...